December 8, 2025BloodOpen Access

Sickling kinetics drive genotype-specific impairment of RBC deformability in sickle cell disease

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Observational analysis revealed faster sickling in HbSS RBCs compared to HbSC, indicating genotype-specific differences in deformability metrics.

Dynamic sickling behavior correlates with RBC mechanical function deterioration, leading to microvascular obstruction.
The study found that HbSS RBCs sickled faster with a T₅₀ of 10.7 minutes compared to 15.7 minutes for HbSC.
Microfluidic assays measured sickling kinetics and RBC deformability, revealing genotype-specific impairments in hemolysis and occlusion.
Therapeutic strategies focusing on polymerization kinetics may help preserve RBC deformability and improve patient outcomes.

Du et al. (2025) studied this question.

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Observational analysis revealed faster sickling in HbSS RBCs compared to HbSC, indicating genotype-specific differences in deformability metrics.