September 10, 2025European Heart JournalOpen Access

Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease

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This study reveals clonal haematopoiesis of indeterminate potential predicts increased mortality in CAD, highlighting TET2 mutations' role.

Clonal haematopoiesis of indeterminate potential is associated with a significant increase in 3-year mortality in patients with coronary artery disease.
TET2 mutations in particular are linked to a higher mortality risk, emphasizing the role of macrophage activation and inflammation.
Using targeted deep sequencing, the study examined 8612 patients with confirmed CAD while assessing their mortality rates over three years.
Enhanced understanding of epigenetic dysregulation could pave the way for new therapeutic strategies focusing on pro-atherogenic macrophage phenotypes.

Scheidt et al. (2025) studied this question.

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This study reveals clonal haematopoiesis of indeterminate potential predicts increased mortality in CAD, highlighting TET2 mutations' role.