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December 8, 2025BloodOpen Access

Infection rates and mortality in multiple myeloma: Impact of blood counts and IgG levels over time

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Authors

NPNeha PuttaguntaPNPhyu Thin NaingKZKelvin Zheng

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Overview

Analysis shows trends in absolute neutrophil count and infection-related mortality in multiple myeloma, highlighting the importance of monitoring blood counts.

Key Points

  • Mortality due to infection was observed in 29% of multiple myeloma patients, with trends in blood counts impacting outcomes.
  • Median absolute neutrophil count was significantly lower at diagnosis in those who died from infection versus other causes of death.
  • Analysis involved a retrospective review of multiple myeloma patients diagnosed from 2021-2023, examining trends in immune parameters.
  • Findings suggest monitoring of absolute neutrophil count and immune parameters may enhance patient care and interventions.

Cite This Study

Puttagunta et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1d3https://doi.org/10.1182/blood-2025-7512
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immune biomarkers of increased risk of infection in multiple myeloma (MM)2025
  2. 2Incidence and risk factors for infections in the real-world setting in newly diagnosed myeloma patients treated with modern induction regimens2025
  3. 3Hematologic predictors of serious infection and impact of serious infection on long-term mortality in AML patients: Insights from propensity-matched real-world cohorts2025
  4. 4Trends and disparities in infection-related mortality among non-Hodgkin lymphoma patients in the United States, 1999–20232025
  5. 5Two decades of infectious mortality in Myelodysplastic Syndromes: An analysis from the CDC wonder database2025