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December 8, 2025Blood

Trends and disparities in hematologic malignancy and sepsis-related mortality in adults aged ≥ 65 years in the United States from 1999 to2023: A CDC wonder database analysis

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Authors

ANAmmar NasirAMAli MuhammadAKAmal Khan

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Overview

Analysis reveals declining mortality rates for hematologic malignancy and sepsis in older adults, indicating ongoing disparities.

Key Points

  • Mortality rates declined from 11.3 in 1999 to 9.5 in 2023 for hematologic malignancy and sepsis.
  • Average mortality rates for men were higher at 14.3 compared to women at 7.4, with women showing a steeper decline.
  • Annual percent change was calculated using Joinpoint regression and confidence intervals were included.
  • Significant disparities in mortality rates across racial and geographical lines need addressing.

Cite This Study

Nasir et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1a5https://doi.org/10.1182/blood-2025-2860
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends and disparities in mortality among patients with anemia and sepsis in the United States from 1999 to 2023: A CDC wonder database analysis2025
  2. 2Acute Myeloid Leukemia and sepsis-related mortality in the United States (U.S.) older adults: Nationwide trends and disparities over 25 years (1999 – 2023)2025
  3. 3Trends and disparities in anemia and pneumonia-related mortality in the United States from 1999 to 2023: A CDC wonder database analysis2025
  4. 4Trends and disparities in premature mortality from hematologic malignancies: Analysis of CDC wonder data, 1999-20202025
  5. 5National trends in sepsis-specific mortality among adults in the United States with multiple myeloma, a 24-year analysis2025