December 8, 2025BloodOpen Access

Distribution and risk for bleeding in patients with cancer by anticoagulant therapy exposure

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Observational analysis found anticoagulant therapy raises bleeding risk in cancer patients, indicating careful monitoring is necessary.

Bleeding requiring hospitalization occurred in 7.1% of patients on anticoagulant therapy within 12 months, compared to 4.1% for controls.
Patients receiving warfarin had a significantly higher bleeding risk with a hazard ratio of 1.68 compared to those not on it.
Propensity score matching created comparable cohorts to assess predictors of bleeding including anemia, chemotherapy, and liver disease.
Anticoagulant therapy's impact on bleeding highlights the need for careful patient assessment before treatment initiation.

Sanfilippo et al. (2025) studied this question.

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December 8, 2025BloodOpen Access

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Authors

Observational analysis found anticoagulant therapy raises bleeding risk in cancer patients, indicating careful monitoring is necessary.

Bleeding requiring hospitalization occurred in 7.1% of patients on anticoagulant therapy within 12 months, compared to 4.1% for controls.
Patients receiving warfarin had a significantly higher bleeding risk with a hazard ratio of 1.68 compared to those not on it.
Propensity score matching created comparable cohorts to assess predictors of bleeding including anemia, chemotherapy, and liver disease.
Anticoagulant therapy's impact on bleeding highlights the need for careful patient assessment before treatment initiation.

Sanfilippo et al. (2025) studied this question.

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