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December 8, 2025BloodOpen Access

Characterization and risk factors of anticoagulation-related bleeding in patients with thrombotic antiphospholipid syndrome: An analysis using a synthetic real-world data platform

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Authors

AMAmir A MahmoudKBKelsey BriaBEBasant Eltaher

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Implication

Analysis shows major bleeding risk factors in thrombotic antiphospholipid syndrome, indicating significant implications for anticoagulant therapy management.

Key Points

  • Major bleeding events occurred in 9.5% of patients with thrombotic antiphospholipid syndrome receiving anticoagulant therapy.
  • Risk factors for bleeding included warfarin use (OR 2.67) and anemia (OR 3.37), highlighting critical clinical concerns.
  • Analysis using synthetic data platform provided insights on bleeding demographics and significant predictors for patients on anticoagulant therapy.
  • Implications emphasize the need for tailored management strategies to mitigate bleeding complications in affected individuals.

Cite This Study

Mahmoud et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d632https://doi.org/10.1182/blood-2025-1329
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Distribution and risk for bleeding in patients with cancer by anticoagulant therapy exposure2025
  2. 2Impact of aspirin use on clinical outcomes in antiphospholipid syndrome patients with arterial thrombosis: A real-world cohort study2025
  3. 3CO04 | Direct oral anticoagulants in antiphospholipid syndrome: a single center real-life experience2025
  4. 4Racial disparities in the incidence and risk factors of major bleeding during extended anticoagulant therapy for venous thromboembolism2025 · 1 citations
  5. 5Development of a new scoring system for predicting recurrent thrombosis in patients with antiphospholipid syndrome2025 · 2 citations