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August 22, 2025Blood AdvancesOpen Access

Comparison of anticoagulants and risk of ischemic stroke in patients with acute cancer-associated venous thromboembolism

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Authors

SMSi‐Rui MaWuhan UniversityYCYu‐Cheng ChangNational Yang Ming Chiao Tung UniversityCCCho‐Han ChiangMount Auburn Hospital

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Implication

Retrospective cohort study compares ischemic stroke risk among anticoagulants in cancer patients with venous thromboembolism, suggesting a potential link with DOAC use.

Key Points

  • Ischemic stroke incidence was 5.6% overall at 6 months, with a significant variation among anticoagulant classes.
  • Patients treated with DOACs had a higher ischemic stroke rate of 6.8%, compared to 4.9% for LMWH and 5.2% for warfarin.
  • The study used a retrospective, population-based cohort design with propensity score matching for treatment groups.
  • Identified key risk factors for ischemic stroke included hypertension, DOAC use, and a history of prior stroke.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68af707c7567bf4f94fec7dehttps://doi.org/10.1182/bloodadvances.2025017523
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Also Consider

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  1. 1Risk of Arterial Thromboembolism in Patients With Cancer2017 · 665 citations
  2. 2A global federated real-world data and analytics platform for research2023 · 836 citations