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December 8, 2025Blood

Increased FXII activation in endovascular treated stroke patients on periprocedural antithrombotic treatment

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Authors

ACAngelique CeulemansBRBob RoozenbeekHSHenri M.H. Spronk

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Overview

Observational analysis revealed increased FXII activation in acute ischemic stroke patients, suggesting a need for improved antithrombotic strategies.

Key Points

  • Antithrombotic treatment in endovascular treatment increased FXII activation compared to EVT only.
  • Neutrophil extracellular traps, linked to coagulation, showed low to moderate correlation with coagulation activity.
  • Assessment utilized multivariable regression to analyze differences in coagulation and outcomes.
  • Improved management may balance efficacy and bleeding risks through targeting FXIIa and NETosis.

Cite This Study

Ceulemans et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e16bhttps://doi.org/10.1182/blood-2025-1358
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