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September 25, 2025Journal of NeuroInterventional Surgery

Acute ischemic stroke and reperfusion drive molecular immune-vascular activations detectable in peripheral blood

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Authors

FRFrancesca RapidoNMNicola MarchiCentre National de la Recherche ScientifiqueJLJulien LabreucheUniversité Claude Bernard Lyon 1

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Implication

Prospective cohort study identifies immune dysregulation and biomarkers in patients undergoing EVT for acute ischemic stroke.

Key Points

  • Higher pre-EVT levels of interleukin-1β and interleukin-4 linked to poorer NIHSS at 24 hours post-stroke.
  • Post-EVT increases in IL-6, VCAM-1, and ICAM-1 indicate ongoing cerebrovascular inflammation.
  • Exploratory study assessed immune responses over time in 52 acute ischemic stroke patients post-reperfusion.
  • Findings suggest that tracking immune markers could assist in predicting patient outcomes after acute ischemic stroke.

Cite This Study

Rapido et al. (2025) studied this question.

synapsesocial.com/papers/68d5d0feddad3c16d4636079https://doi.org/10.1136/jnis-2025-023885
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Stroke-induced Immunodeficiency Promotes Spontaneous Bacterial Infections and Is Mediated by Sympathetic Activation Reversal by Poststroke T Helper Cell Type 1–like Immunostimulation2003 · 930 citations