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December 8, 2025BloodOpen Access

Combinations of high risk cytogenetic events in multiple myeloma drive distinct immune remodeling patterns and worse outcomes

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Authors

CAChaitanya R. AcharyaMDMadhav V. DhodapkarSPSamir Parekh

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Overview

Combinations of high-risk cytogenetic events show worse progression-free survival in multiple myeloma, suggesting distinct immune alterations.

Key Points

  • Multi-hit high risk cytogenetics predicted significantly worse progression free survival, with HR=2.34.
  • Single-cell RNA sequencing revealed immune population shifts in patients with high-risk alterations.
  • Distinct immune profiles were noted based on cytogenetic profiles, emphasizing heterogeneity in multiple myeloma.
  • Findings indicate that immune remodeling may complicate treatment strategies, particularly for multi-hit patients.

Cite This Study

Acharya et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236de87https://doi.org/10.1182/blood-2025-2179
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ultra high-risk multiple myeloma with early mortality despite quad-class and BCMA-directed therapies: Clinical and molecular insights2025
  2. 2Multi-omics reveals immune features in immune and non-immune cells, an IFN-γ/IFN-α-B2M positive feedback loop, and targeted metabolic therapy in multiple myeloma2025
  3. 3Dissecting the multiple myeloma survival niche to improve novel treatment strategies2025
  4. 4Navigating the Prognostic Complexity of IgH Cytogenetic Abnormalities in Multiple Myeloma Among Diverse IgH Cytogenetic Abnormalities–Involved High‐Risk Stratifications2025
  5. 5Single-cell DNA sequencing uncovers synergistic co-mutations in multiple myeloma2025