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December 8, 2025BloodOpen Access

Prognostic impact of co-occurring mutations in NPM1-mutated Acute Myeloid Leukemia

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Authors

RSRafeh SafdarHDHardik DandYAYanal Alnimer

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Overview

Retrospective analysis shows lower remission rates in acute myeloid leukemia with DNMT3A mutations, suggesting implications for treatment decisions.

Key Points

  • Complete remission rates drop significantly with the presence of co-mutations, signaling a need for revised risk assessments.
  • Among 104 NPM1-mutated acute myeloid leukemia patients, over 93% had additional mutations, most commonly DNMT3A.
  • This analysis utilized a retrospective cohort design from patients diagnosed and treated at a single center.
  • High co-mutation levels may lead to reduced overall survival, emphasizing the importance of mutation profiles in treatment planning.

Cite This Study

Safdar et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e0aahttps://doi.org/10.1182/blood-2025-1729
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Value of Molecular and Clinical Features in Patients with NPM1 Gene Mutation in Acute Myeloid Leukemia2025 · 1 citations
  2. 2Prognostic covariates associated with outcomes in patients with <i>NPM1</i>-mutated acute myeloid leukemia2025 · 3 citations
  3. 3RAS mutations negate the favorable impact of NPM1 in older patients with newly diagnosed Acute Myeloid Leukemia treated with ven/HMA2025
  4. 4Co-mutation signatures are age-dependent and impact the prognosis in &lt;i&gt;NPM1&lt;/i&gt;-mutated acute myeloid leukemia: a PETHEMA multicenter study2026
  5. 5DNMT3A and NPM1 co-mutations in Acute Myeloid Leukemia (AML): A genomic landscape study2025