Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 18, 2026HaematologicaOpen Access

Co-mutation signatures are age-dependent and impact the prognosis in NPM1-mutated acute myeloid leukemia: a PETHEMA multicenter study

View Full Paper
Ask AI
Bookmark
Share

Authors

JGJosé Vicente GilCSClaudia SargasARAyala Rp

Discussion

Loading...

Member takes

Overview

Retrospective analysis uncovers age-structured co-mutation impacts on prognosis in adults with NPM1-mutated acute myeloid leukemia, indicating clinical significance.

Key Points

  • This research aims to explore the age-dependent co-mutation profiles in NPM1-mutated acute myeloid leukemia and their prognostic implications.
  • Retrospective analysis of 1,360 adults from a multicenter cohort.
  • Mapping of co-mutation architecture and its correlation with age and clinical outcomes.
  • Assessment of overall survival, relapse-free survival, and event-free survival stratified by mutation status.
  • Co-mutations present in 97% of patients; median of 3 mutations per patient.
  • SRSF2 and DNMT3A independently associated with worse outcomes; FLT3-OTHER improved overall survival.
  • Older patients with specific co-mutations showed distinct clinical phenotypes impacting treatment outcomes.

Cite This Study

Gil et al. (2026) studied this question.

synapsesocial.com/papers/6a5b183e18557b26c203a249https://doi.org/10.3324/haematol.2026.301025
View Full Paper
Ask AI
Bookmark
Share