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December 8, 2025BloodOpen Access

Geographic, demographic, and risk factor profiles of acute myeloid and acute lymphoblastic leukemia in the United States: Insights from the global burden of disease study 2021

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Authors

KSKrishna Sai Kiran SakalabaktulaYGYashaswi GuntupalliRNRithish Nimmagadda

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Overview

Analysis shows rising acute myeloid leukemia incidence and prevalence in the US, indicating smoking and high BMI as key risk factors.

Key Points

  • Incidence of acute myeloid leukemia rose slightly, with age-standardized rates highest in Kentucky and Michigan.
  • Prevalence for acute lymphoblastic leukemia peaked in Arizona, with a male predominance across most metrics.
  • Observed trends indicate slight increases in acute myeloid leukemia metrics, while acute lymphoblastic leukemia shows declines.
  • Geographic variation emphasizes the need for targeted interventions for smoking, high BMI, and occupational carcinogens.

Cite This Study

Sakalabaktula et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfd4https://doi.org/10.1182/blood-2025-6837
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  5. 5The global, regional, and national burden of acute lymphoblastic leukemia, 1990 to 2021: a cross-sectional analysis from the 2021 global burden of disease study2025 · 3 citations