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December 8, 2025BloodOpen Access

Two-decade trends and future projections of heart failure mortality in Myelodysplastic Syndromes: A nationwide population-based study (1999–2030)

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Authors

ADAllah DadHAHafsa AhmedMKMadhurendra Kumar

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Overview

Population-based analysis showed rising heart failure mortality in MDS, indicating persistent risk and disparities.

Key Points

  • To analyze heart failure mortality trends among individuals with myelodysplastic syndromes over two decades.
  • Retrospective population-based analysis using CDC WONDER database
  • Calculated age-adjusted mortality rates from 1999 to 2023
  • Used Joinpoint regression and ARIMA models for trend analysis and forecasting
  • Conducted subgroup analyses based on sex, race, ethnicity, and region
  • 4,947 heart failure-related deaths observed among MDS patients from 1999 to 2023
  • Age-adjusted mortality rates increased from 2.5 per million in 1999 to 2.7 in 2023
  • Gender-specific trends showed a 5% increase in males, whereas females experienced a 5% decrease
  • Racial disparities highlighted, with White individuals having the highest mortality rates
  • Forecasted rates suggest a continued increase in HF-related mortality among MDS patients through 2030

Cite This Study

Dad et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d14dhttps://doi.org/10.1182/blood-2025-4433
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