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December 8, 2025Blood

Prognostic significance of PNH clones in aplastic anemia treated with immunosuppression or allogeneic HSCT

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Authors

AHAlfadil HaroonAAAbdullah AlamerAHAmr Hanbali

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Overview

Retrospective analysis shows improved survival in aplastic anemia patients with PNH clones, suggesting better outcomes after immunosuppression or stem cell transplantation.

Key Points

  • PNH-positive patients had a 100% overall survival after immunosuppression compared to 72.4% for PNH-negative patients.
  • Cumulative chronic GvHD incidence was notably lower in PNH-positive recipients post HSCT, at 4% versus 27% for PNH-negative.
  • Analysis involved 207 aplastic anemia patients treated between 2004 and 2024, followed for a median duration of 102 months.
  • Further studies are needed to understand PNH clone effects on GvHD incidences.

Cite This Study

Haroon et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df72https://doi.org/10.1182/blood-2025-4967
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PO60 | Asymptomatic PNH clone in acquired aplasia (AA)2025
  2. 2PNH clones prevalence study in ph-negative myeloproliferative neoplasms: a multicenter Italian study2025 · 3 citations
  3. 3Clonal architecture and dynamics of somatic evolution in aplastic anemia and paroxysmal nocturnal hemoglobinuria2025 · 1 citations
  4. 4Correlation between efficacy, clonal dynamics evolution, and development of bone marrow failure in PNH/AA syndrome treated with complement inhibitors: A single-center cohort study2025
  5. 5Paroxysmal Nocturnal Hemoglobinuria with Large Clones in Non-Hypoplastic Myelodysplastic Syndrome: Report of Two Cases2025 · 1 citations