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August 22, 2025Annals of HematologyOpen Access

PNH clones prevalence study in ph-negative myeloproliferative neoplasms: a multicenter Italian study

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Authors

ADAlessandra D’AddioMRMichela RondoniMSMarzia Salvucci

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Overview

Multicenter analysis finds PNH clones in 3.23% of Ph-negative MPN patients, highlighting genetic mutation associations.

Key Points

  • The prevalence of PNH positive clones was 3.23%, indicating potential genetic mutations' role in malignancies.
  • Among 119 Ph-negative MPN patients, all three with PNH clones had splenomegaly, lacking thrombosis events.
  • Next generation sequencing was conducted in 15 cases, uncovering significant mutations related to PNH positivity.
  • Clinical implications suggest that genetic mutations like CALR and JAK2V617F may worsen MPN outcomes.

Cite This Study

D’Addio et al. (2025) studied this question.

synapsesocial.com/papers/68af73697567bf4f94fed58ahttps://doi.org/10.1007/s00277-025-06556-y
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