Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
December 8, 2025Blood

Elevated d-dimer predicts worse outcomes in hospitalized adults with sickle cell crisis: A real-world multicenter study

View Full Paper
Ask AI
Bookmark
Share

Authors

DSDivya SamatSSShivam Singh

Discussion

Loading...

Member takes

Overview

Retrospective cohort study evaluates elevated D-dimer as a biomarker of adverse outcomes in sickle cell disease, indicating hospitalization and transfusion needs increase.

Key Points

  • Elevated d-dimer levels predict a 40.6% risk of acute chest syndrome in hospitalized adults with sickle cell disease, compared to 26.7% in non-elevated cases.
  • Blood transfusion was needed in 47.2% of patients with elevated d-dimer, versus 33.8% in those with lower levels, highlighting its clinical significance.
  • This retrospective cohort study used propensity score matching to assess outcomes in 636 adults hospitalized with sickle cell crisis across multiple centers.
  • D-dimer may serve as a valuable prognostic biomarker for guiding management in sickle cell disease, although mortality data suggests further investigation is warranted.

Cite This Study

Samat et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de0bhttps://doi.org/10.1182/blood-2025-4748
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1D-dimer Levels as a Prognostic Inpatient Mortality Indicator in COVID-19 Patients: Insights from a Cross-Sectional Study2025 · 1 citations
  2. 2Elevated D-Dimer Levels in Older Medical Emergency Department Patients: Real-Life Data on Associations with Severe Acute Medical Problems and Occult Malignancy2025
  3. 3Association of D-dimer Levels in Acute Ischaemic Stroke Patients at Tertiary Care Centre in Northern India: A Prospective Observational Study2025
  4. 4Admission D-dimer is associated with subsequent cardiac rupture after acute myocardial infarction: a frequency-matched case-control study2026
  5. 5Elevated on-treatment D-dimer level is associated with major bleeding during extended anticoagulation for venous thromboembolism2026