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November 28, 2025Emergency Care and MedicineOpen Access

Elevated D-Dimer Levels in Older Medical Emergency Department Patients: Real-Life Data on Associations with Severe Acute Medical Problems and Occult Malignancy

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Authors

BEBeau ElshoutNZNoortje ZelisJBJacqueline Buijs

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Overview

Cohort study shows elevated D-Dimer indicates sepsis and occult malignancy in older ED patients, suggesting diagnostic caution.

Key Points

  • Elevated D-Dimer levels predict serious conditions like sepsis in older ED patients, with 69.8% showing abnormal levels.
  • Cox regression analysis revealed elevated D-Dimer also suggests potential occult malignancy, diagnosed in 9.2% after 6 months.
  • D-Dimer levels ≥2000 µg/L significantly linked to malignancy, with higher odds for higher levels noted in the study population.
  • Finding emphasizes careful evaluation required in older patients, as low D-Dimers suggest minimal risk for occult malignancy.

Cite This Study

Elshout et al. (2025) studied this question.

synapsesocial.com/papers/6928f126a65b730b9ea7a54bhttps://doi.org/10.3390/ecm2040056
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