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This is a In Vitro Study study.

December 8, 2025BloodOpen Access

Cryo-electron tomography of sickled red blood cells towards a high-resolution in situ structure of HbS polymers and red cell cytoskeleton

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Red blood cells show abnormal structure and polymerization of HbS, impacting cell function significantly.
Mitochondria appear retained and dysfunctional in red blood cells from patients with Sickle Cell Disease, indicating potential metabolic disturbances.
Cryogenic electron tomography was utilized to reveal high-resolution images of sickled red blood cells and their cytoplasmic features within a controlled environment.
Understanding the formation of HbS polymers may highlight new avenues for therapeutic interventions in treating Sickle Cell Disease.

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Implication

Cryogenic electron tomography demonstrates the intracellular structure of sickled red blood cells, suggesting insights into potential therapies for Sickle Cell Disease.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236dde1 https://doi.org/10.1182/blood-2025-2922

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Implication

Cryogenic electron tomography demonstrates the intracellular structure of sickled red blood cells, suggesting insights into potential therapies for Sickle Cell Disease.

Cryo-electron tomography of sickled red blood cells towards a high-resolution in situ structure of HbS polymers and red cell cytoskeleton

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Discussion

Implication

Cite This Study

Cryo-electron tomography of sickled red blood cells towards a high-resolution in situ structure of HbS polymers and red cell cytoskeleton

Key Points

Discussion

Implication

Cite This Study

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