Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 24, 2026BiomedicinesOpen Access

Sickle Cell Disease: From Ancient Origins to Modern Breakthroughs in Gene Therapy

View Full Paper
Ask AI
Bookmark
Share

Authors

BIBawo IkoloMOMathew OyelamiOMOdinaka Mgbeke

Discussion

Loading...

Member takes

Overview

Review traces Sickle Cell Disease from historical roots to recent gene therapy interventions, highlighting implications for treatment.

Key Points

  • This review aims to explore the historical origins, molecular characterization, and current therapeutic strategies for Sickle Cell Disease.
  • Examined the molecular basis of Sickle Cell Disease and its clinical manifestations.
  • Reviewed interventions, including pharmacological and gene therapy approaches.
  • Critically analyzed the challenges in treatment access, costs, and ethical considerations.
  • Hematopoietic stem cell transplantation remains the standard for curing SCD.
  • Regulatory approvals of CRISPR/Cas9-based and lentiviral vector-based therapies mark significant advancements.
  • Challenges include prohibitive treatment costs and healthcare inequities.

Cite This Study

Ikolo et al. (2026) studied this question.

synapsesocial.com/papers/6a630150395161722cd15fb6https://doi.org/10.3390/biomedicines14071649
View Full Paper
Ask AI
Bookmark
Share