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December 8, 2025BloodOpen Access

Thyroid diffuse large B-cell lymphoma in China: Multicenter study of diagnosis, clinical features, treatment efficacy, prognostic factors, and genomic alterations

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Authors

HSHao SunChongqing UniversityGCGuohui CuiHuazhong University of Science and TechnologySYShenmiao YangPeking University

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Overview

Multicenter study reveals primary TDLBCL shows better survival and treatment efficacy than secondary forms, suggesting clinicians focus on unique prognostic factors.

Key Points

  • Primary thyroid diffuse large B-cell lymphoma demonstrated significantly improved progression-free survival compared to secondary cases.
  • A multicenter retrospective analysis of 190 patients indicated elevated lactate dehydrogenase adversely affects prognosis.
  • Targeted sequencing revealed mutations in TP53 and its implications on treatment outcomes highlight the need for tailored therapies.
  • Adverse prognostic factors like Ann Arbor stage and extranodal involvement stress the importance of early diagnosis and intervention.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd75https://doi.org/10.1182/blood-2025-1902
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  4. 4Clinical characteristics and treatment evaluation of T-cell lymphoblastic lymphoma in Chinese children and adolescents：a multicenter clinical study of China-net childhood lymphoma-lbl-20172025
  5. 5Prognostic value of baseline FDG PET/CT total metabolic tumor volume and MYC/BCL2 double expression status in patients with diffuse large B-cell lymphoma2025