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December 8, 2025Blood

Integrating genomic features for prognosis in Chinese patients  with B-cell lymphoma following R-CHOP therapy

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Authors

YHYongxian HuImmunité et Cancer

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Overview

Analysis reveals genomic biomarkers like TP53 and BCL2 predict treatment response in B-cell lymphoma, suggesting improved prognosis using new models.

Key Points

  • Mutations in TP53 and BCL2 are critical biomarkers related to poor progression-free survival in B-cell lymphoma patients.
  • Significant hazard ratios were observed for TP53 (HR=2.78) and BCL2 (HR=2.54), implying their association with treatment outcomes.
  • Cox proportional hazards models analyzed genetic mutations' impact on survival, enhancing prognostic models' accuracy.
  • A novel risk score improved over the International Prognostic Index in predicting patient relapse rates after therapy.

Cite This Study

Yongxian Hu (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4b7https://doi.org/10.1182/blood-2025-3670
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Also Consider

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  1. 1Real-world patient-based next-generation sequencing assessments identify a high-risk subgroup and associated gene signature in diffuse large B cell lymphoma2025
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  4. 4Thyroid diffuse large B-cell lymphoma in China: Multicenter study of diagnosis, clinical features, treatment efficacy, prognostic factors, and genomic alterations2025
  5. 5Construction of a prognostic model for new diffuse large B-cell lymphoma and research on risk factors for secondary central nervous system infiltration2025