Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Ferroptosis activates NK and CAR T cell-mediated anti-tumor immunity in Acute Myeloid Leukemia

View Full Paper
Ask AI
Bookmark
Share

Authors

SGSaurabh Kumar GuptaKKKazuharu KamachiLLLi Li

Discussion

Loading...

Member takes

Overview

Ferroptosis enhances anti-tumor immunity in acute myeloid leukemia, indicating immunogenic cell death plays a key role.

Key Points

  • Ferroptosis enhances NK cell-mediated anti-AML effects, promoting targeted therapy.
  • GPX4 inhibition significantly increases extracellular ATP and HMGB1, while CAR T cells show amplified activity.
  • Assessment using ferroptosis inhibitors demonstrated enhanced immune responses against AML cells.
  • Highlights the potential for ferroptosis-based immunotherapy strategies in overcoming treatment resistance.

Cite This Study

Gupta et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dcdfhttps://doi.org/10.1182/blood-2025-1496
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1GPX4 is a key ferroptosis regulator orchestrating T cells and CAR-T-cells sensitivity to ferroptosis2025
  2. 2Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma that Drives Antitumor Immunity2025 · 5 citations
  3. 3Ferroptosis escape in AML stem cells uncovered by single-cell profiling and reversed by STAT3/NRF2 inhibition2025
  4. 4Inducing ferroptosis to improve cancer therapy: a promising tool for enhancing immunotherapy2025
  5. 5Enhancement of ferroptosis in escape variant tumor cells by IFN-γ derived from antigen-specific T cells controls tumor with heterogeneity2026