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December 8, 2025Blood

Ferroptosis escape in AML stem cells uncovered by single-cell profiling and reversed by STAT3/NRF2 inhibition

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Authors

RGRitu GuptaVSVivek SinghRSRomila Singh

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Overview

Ferroptosis pathway activation reduces chemoresistance in leukemic stem cells, suggesting new therapeutic strategies.

Key Points

  • Targeting ferroptosis resulted in reduced chemoresistance in leukemic stem cells, improving treatment outcomes.
  • Differential gene expression analysis highlighted the role of STAT3 and NRF2 in regulating ferroptosis-related genes.
  • Single-cell profiling revealed significant differences in gene expression between leukemic and healthy stem cells.
  • Combining STAT3 and NRF2 inhibitors enhanced ferroptosis in AML stem cells, indicating a novel therapeutic approach.

Cite This Study

Gupta et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dcd8https://doi.org/10.1182/blood-2025-1487
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Also Consider

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  1. 1Ferroptosis activates NK and CAR T cell-mediated anti-tumor immunity in Acute Myeloid Leukemia2025 · 1 citations
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  3. 3Targeting NRF2 and FSP1 to Overcome Ferroptosis Resistance in TSC2-Deficient and Cancer Cells2025
  4. 4Targeting NRF2 and FSP1 to Overcome Ferroptosis Resistance in TSC2-Deficient and Cancer Cells2025 · 5 citations
  5. 5Targeting ALDH16A1 mediated thioredoxin lysosomal degradation to enhance ferroptosis susceptibility in SMARCA4-deficient NSCLC2025 · 8 citations