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August 19, 2025Cancer Research

Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma that Drives Antitumor Immunity

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Authors

KFKarine Flem‐KarlsenRTRonan TaltyMMMeaghan K. McGeary

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Overview

Single-cell RNA sequencing reveals ferroptosis drives immune responses in melanoma, implying immunotherapy potential.

Key Points

  • Ferroptosis significantly increased in melanoma undergoing immune-mediated regression, indicating its role in antitumor immunity.
  • Single-cell RNA sequencing revealed a prominent ferroptosis signature in mouse melanomas with varying immune responses.
  • CD8+ T cells downregulated GPX4 to promote ferroptosis in melanoma cells, highlighting their role in immune-mediated tumor death.
  • Results suggest modulating ferroptosis could enhance immunotherapy effectiveness in treating melanoma.

Cite This Study

Flem‐Karlsen et al. (2025) studied this question.

synapsesocial.com/papers/68af33efcf1dd9ea359e9718https://doi.org/10.1158/0008-5472.can-24-1952
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1GPX4 is a key ferroptosis regulator orchestrating T cells and CAR-T-cells sensitivity to ferroptosis2025
  2. 2GPX4 in the Tumor Microenvironment: Not Just Inhibiting Ferroptosis, but Immuno-Metabolic Regulation2026
  3. 3Ferroptosis activates NK and CAR T cell-mediated anti-tumor immunity in Acute Myeloid Leukemia2025 · 1 citations
  4. 4Lipid Composition Alters Ferroptosis Sensitivity2025
  5. 5Enhancement of ferroptosis in escape variant tumor cells by IFN-γ derived from antigen-specific T cells controls tumor with heterogeneity2026