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December 8, 2025BloodOpen Access

Epidemiologic insights into early-onset myelodysplastic syndrome: A longitudinal SEER analysis (2000-2022)

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Authors

JAJowan Al‐NusairKSKatherine M. Steele

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Overview

Retrospective cohort analysis identifies stable early-onset MDS incidence, suggesting environmental influences on survival rates.

Key Points

  • Early-onset myelodysplastic syndrome has a stable incidence of 0.4 per 100,000 over two decades, showing geographic variation.
  • The analysis involved over 797 million person-years, highlighting demographic patterns and survival disparities.
  • Relative survival estimates at 12 and 60 months reveal females more likely to survive than males, with rates of 87.6% and 79.9%.
  • Environmental influences may impact the geography of early-onset MDS, pointing to the need for further studies.

Cite This Study

Al‐Nusair et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc03https://doi.org/10.1182/blood-2025-7374
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends and disparities in myelodysplastic Syndrome–Associated mortality in the u.S. from 1999 to 2020: A population-based study using the CDC wonder database2025
  2. 2Clinical, genetic, and pathologic differences across race, ethnicity, and sex in patients with MDS and precursor conditions from the national MDS natural history study2025
  3. 3Blood and filters: The intersection of myelodysplastic syndrome and renal failure in u.S. mortality trends (1999–2023)2025
  4. 4Temporal trends and demographic disparities in myelodysplastic syndrome-associated mortality in Acute Myeloid Leukemia patients in the United States: A population-based analysis (1999–2023)2025
  5. 5Longitudinal trends (1999–2023) and forecasted mortality (2024–2030) in sepsis-associated mortality among patients with Myelodysplastic Syndromes in the United States.2025