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September 10, 2025Cell Reports MedicineOpen Access

Whole-genome sequencing reveals three follicular lymphoma subtypes with distinct cell of origin and patient outcomes

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Authors

WRWeicheng RenKarolinska InstitutetMYMing‐Yu YangChina University of Petroleum, BeijingXWXianhuo WangTianjin Medical University Cancer Institute and Hospital

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Implication

Whole-genome sequencing identifies three follicular lymphoma subtypes, revealing distinct origins and outcomes, suggesting novel treatment strategies.

Key Points

  • Three follicular lymphoma subtypes were identified, each linked to different patient outcomes.
  • Subtype C1 has favorable prognoses and is enriched for genetic variations related to BCL6 and NF-κB.
  • C2 is defined by BCL2-IGH translocations and distinct chromatin modifier mutations.
  • The discovery of these subtypes highlights the molecular diversity of follicular lymphoma.

Cite This Study

Ren et al. (2025) studied this question.

synapsesocial.com/papers/68c24236b210217d647a2ea9https://doi.org/10.1016/j.xcrm.2025.102278
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