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December 8, 2025BloodOpen Access

Dissecting clonal hematopoiesis in diffuse large B-cell lymphoma through multi-compartment genomic profiling

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Authors

RBRiccardo BrunaRDRiccardo DondolinFMFrancesca Mercalli

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Overview

Observational analysis demonstrated clonal hematopoiesis affects molecular subtypes in DLBCL, indicating potential clinical significance.

Key Points

  • Clonal hematopoiesis was detected in 29.4% of patients, with DNMT3A mutations prevalent among cases.
  • Genomic profiling utilized CAPP-Seq in 366 samples from 169 DLBCL patients treated with R-CHOP regimens.
  • The prevalence of clonal hematopoiesis and VAF significantly increased during treatment, indicating dynamic changes.
  • Findings suggest molecular subtypes associated with clonal hematopoiesis may reflect underlying biological mechanisms.

Cite This Study

Bruna et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e57bhttps://doi.org/10.1182/blood-2025-3537
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