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December 8, 2025BloodOpen Access

Old mismatched donors are associated with inferior outcomes after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndrome, but not in Acute Myeloid Leukemia

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Authors

YKYoungil KohHKHyo Jung Kim

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Overview

Analysis shows survival disparity based on donor type in myelodysplastic syndrome, suggesting careful donor selection.

Key Points

  • Old mismatched donors lead to lower survival in myelodysplastic syndrome but not in acute myeloid leukemia.
  • Survival rates differed significantly between matched and mismatched donors, especially among MDS patients.
  • Retrospective analysis of 320 patients undergoing allogeneic hematopoietic stem cell transplantation at a major hospital revealed critical insights.
  • Highlighting the need for improved donor selection strategies can enhance patient outcomes significantly.

Cite This Study

Koh et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da2chttps://doi.org/10.1182/blood-2025-6052
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Older donor age is not associated with inferior survival in contemporary haploidentical transplantation2025
  2. 2Matched sibling donors still provide superior survival outcomes in older patients with AML in second complete remission. a study from the global committee and the acute leukemia working party of the european society for blood and marrow transplantation2025
  3. 3Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC2025 · 1 citations
  4. 4Donor Age ≥30 Years as an Independent Predictor of Inferior Outcomes After Haploidentical Hematopoietic Cell Transplantation in Acute Myeloid Leukemia. Study Conducted on Behalf of GETH-TC2025
  5. 5Age-related differences in donor selection priorities for allogeneic hematopoietic transplantation2025 · 2 citations