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December 8, 2025BloodOpen Access

Mortality in sickle cell disease: A report from the grndad registry

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Authors

JSJohn J. StrouseJLJane A. Little

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Overview

Longitudinal analysis reports 11.7 deaths per 1,000 person-years in sickle cell disease patients, highlighting treatment impact among demographics.

Key Points

  • Mortality rate of 11.7 deaths per 1,000 person-years underscores the ongoing challenges of managing sickle cell disease.
  • Statistical analysis revealed a higher mortality rate in adults than in pediatric patients, with notable risks linked to disease type.
  • Longitudinal analysis conducted through the patient registry involved 5,198 individuals across 56 clinical sites, enhancing data quality.
  • Findings suggest no clear improvement in mortality rates, despite advancements in treatment for sickle cell disease.

Cite This Study

Strouse et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9b6https://doi.org/10.1182/blood-2025-2973
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Also Consider

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  1. 1Sickle cell disease survival analysis at a large United States southern comprehensive sickle cell disease center: 1995 - 20222025
  2. 2Grandchildren of <scp>GRNDaD</scp>: Shifts in disease‐modifying therapy at the adolescent transition in sickle cell disease2025 · 2 citations
  3. 3Sickle cell disease in europe: A cross-border real-world data analysis from the radeep registry2025
  4. 4Demographics and Trends of Sudden Cardiac Death‐Related Mortality in the United States, 1999 to 20222025 · 8 citations
  5. 5Disparities in sickle cell disease related mortality in the US-Mexico border region from 1999 to 2020: A CDC wonder Study2025