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December 8, 2025Blood

Sickle cell disease survival analysis at a large United States southern comprehensive sickle cell disease center: 1995 - 2022

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Authors

MCM. L. ChanceJLJeffrey D. LebensburgerHCHenry Carlton

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Overview

Retrospective cohort analysis found 97.9% survival among pediatric sickle cell disease patients, suggesting critical needs in mortality reduction strategies.

Key Points

  • Overall mortality for patients with sickle cell anemia was 3.3%, while for other sickle cell genotypes it was only 0.7%.
  • The most prevalent cause of death in our cohort was complications from hematopoietic stem cell transplant, followed by cardiopulmonary issues.
  • 70% of deaths occurred in pediatric patients or after transition to adult care, highlighting two critical age ranges.
  • An urgent need for improved community surveillance and post-HSCT monitoring remains essential to reduce mortality.

Cite This Study

Chance et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d8adhttps://doi.org/10.1182/blood-2025-6225
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mortality in sickle cell disease: A report from the grndad registry2025 · 1 citations
  2. 2Improvement of sickle cell disease care mitigates the healthcare utilization induced by increased prevalence: Experience of a tertiary pediatric center2025
  3. 3Longterm survival and late effects following hematopoietic cell transplantation for sickle cell disease into a modern era: A center for international blood and marrow transplant research (CIBMTR) analysis2025 · 2 citations
  4. 4The contemporary adolescent and young adult sickle cell population in Malawi2025
  5. 5Implementation of a comprehensive sickle cell center leads to improved access to care and decreased acute care use2026