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December 8, 2025BloodOpen Access

Single-unit cord blood transplantation reduces the risk of relapse and improves leukemia-free survival compared to other donor sources in allo-HSCT for patients with high-risk acute myeloid leukemia

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Authors

MKMika KunoOWOtoya WatanabeDKDaisuke Kaji

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Overview

Observational analysis shows improved leukemia-free survival in acute myeloid leukemia with cord blood transplants, indicating a strong graft-versus-leukemia effect.

Key Points

  • Cord blood transplantation results in lower relapse rates compared to alternative donor sources in high-risk acute myeloid leukemia.
  • Five-year leukemia-free survival was higher at 49.6% for cord blood versus 35.4% for other donors, emphasizing its efficacy.
  • Multivariate analysis revealed significant associations between cord blood and favorable leukemia-free survival outcomes in high-risk patients.
  • These findings suggest the benefit of using cord blood as a viable option for patients with challenging leukemia profiles.

Cite This Study

Kuno et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d936https://doi.org/10.1182/blood-2025-591
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single vs double cord blood transplantation: Improved engraftment with comparable efficacy2025
  2. 2Better outcomes with haploidentical than matched sibling donors for adult AML patients allo-transplanted in CR with detectable MRD: A study from the global committee and the ALWP of the EBMT.2025 · 1 citations
  3. 3Optimizing Timing and Preparation for Allogeneic Hematopoietic Stem Cell Transplantation in Higher-Risk Myelodysplastic Syndromes2025
  4. 4Superior outcome from frontline cord blood transfusion combined HLA-full-matched unrelated donor hematopoietic stem cell transplantation for aplastic anemia2025 · 1 citations
  5. 5Matched sibling donors still provide superior survival outcomes in older patients with AML in second complete remission. a study from the global committee and the acute leukemia working party of the european society for blood and marrow transplantation2025