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December 8, 2025Blood

Single vs double cord blood transplantation: Improved engraftment with comparable efficacy

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Authors

AAAlessandra AzureFGFrédéric GrandjeanNANaveed Ali

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Overview

Retrospective analysis shows improved engraftment with single cord blood transplantation in patients, suggesting comparable efficacy for both approaches.

Key Points

  • To compare clinical outcomes of single and double cord blood transplantation in patients with hematologic malignancies.
  • Retrospective analysis of 315 patients undergoing either single or double cord blood transplantation.
  • Evaluation of engraftment, overall survival, and disease-free survival using Kaplan–Meier and Cox regression methods.
  • Assessment of cumulative incidences of graft-versus-host disease and non-relapse mortality.
  • sCBT recipients exhibited significantly faster engraftment compared to dCBT recipients in terms of neutrophils and platelets.
  • 5-year overall survival was higher for sCBT compared to dCBT (70% vs 58%).
  • Lower rates of non-relapse mortality were observed after sCBT compared to dCBT (14% vs 29%).

Cite This Study

Azure et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d03ehttps://doi.org/10.1182/blood-2025-7736
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Avoidance of ATG improves outcomes in double-cord blood transplantation for hematological malignancies2025
  2. 2Single-unit cord blood transplantation reduces the risk of relapse and improves leukemia-free survival compared to other donor sources in allo-HSCT for patients with high-risk acute myeloid leukemia2025
  3. 3Outcomes of stem cell boost (SCB) versus supportive care alone for prolonged cytopenias after chimeric antigen receptor T cell therapy (CAR-T) in relapsed/refractory multiple myeloma (RRMM): A muli-center real-world analysis2025 · 2 citations
  4. 4Reduced intensity haploidentical bone marrow transplantation in children with severe sickle cell disease (SCD): BMT CTN 15072025 · 4 citations
  5. 5CD3⁺cell dose is an independent risk factor for grade II–IV aGVHD following cord blood transplantation in children with aplastic anemia2025