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December 8, 2025BloodOpen Access

Detection of minute FLT3-ITD clones at day +30 post-allo-HSCT predicts high relapse risk and informs maintenance therapy in AML: A niche cohort study

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Authors

APAiming PangEJErlie Jiang

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Overview

Observational analysis detected FLT3-ITD clones in 27.2% of patients at day +30, indicating that personalized maintenance therapy may improve outcomes in AML.

Key Points

  • Detection of minimal FLT3-ITD clones predicts a significantly higher relapse risk in acute myeloid leukemia patients post-transplant.
  • Among 136 patients who were CE-negative, 37 (27.2%) had detectable FLT3-ITD clones at day +30, affecting cumulative incidence rates.
  • Assessment used high-sensitivity next-generation sequencing to identify relapse risk ahead of conventional methods.
  • Early detection may enable personalized decisions for maintenance therapy, improving post-transplant survival in AML.

Cite This Study

Pang et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d934https://doi.org/10.1182/blood-2025-589
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clonal dynamics of FLT3-ITD positive acute myeloid leukemia following relapse after allogeneic stem cell transplantation2025
  2. 2Diagnostic evaluation methods and prognostic impact of FLT3-ITD microclones in Acute Myeloid Leukemia (AML): A retrospective multicenter study on behalf of the EHA AML-specialized working group (SWG)2025 · 1 citations
  3. 3Impact of initial FLT3-ITD mutated clone numbers on clinical outcomes in Acute Myeloid Leukemia2025
  4. 4A novel multi-target NGS application for molecular monitoring of measurable residual disease in Acute Myeloid Leukemia2025 · 2 citations
  5. 5Prognostic factors for newly diagnosed Acute Myeloid Leukemia with FLT3-TKD - a multicenter retrospective study2025