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December 8, 2025Blood

A novel multi-target NGS application for molecular monitoring of measurable residual disease in Acute Myeloid Leukemia

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Authors

FLFederico LussanaOSOrietta SpinelliARAlessandro Rambaldi

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Overview

Observational analysis identified somatic mutations in acute myeloid leukemia post-hematopoietic stem cell transplantation, suggesting the utility of next generation sequencing for risk assessment.

Key Points

  • Persistence of mutations in remission was associated with unfavourable outcomes following transplantation.
  • Median age of patients at transplantation was 58 years, with significant somatic mutations detected at diagnosis.
  • NGS method provided a high sensitivity level with extensive coverage in mutation detection.
  • Findings highlight the relevance of signaling gene mutations for relapse-free survival in acute myeloid leukemia.

Cite This Study

Lussana et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e570https://doi.org/10.1182/blood-2025-3513
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Monitoring of measurable residual disease by next‐generation sequencing in patients with acute myeloid leukaemia2025 · 5 citations
  2. 2Integration of Next-Generation Sequencing in Measurable Residual Disease Monitoring in Acute Myeloid Leukemia and Myelodysplastic Neoplasm2025 · 5 citations
  3. 3Comparative evaluation of NGS-based MRD detection in AML using longitudinal matched bone marrow and blood samples2025
  4. 4Outcomes following MRD relapse in AML patients monitored by droplet digital PCR2025
  5. 5Post-induction minimal residual disease assessment by flow cytometry and molecular biology enables prognostic stratification of patients with NPM1-mutated Acute Myeloid Leukemia: A dataml registry study.2025