Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Clonal dynamics of FLT3-ITD positive acute myeloid leukemia following relapse after allogeneic stem cell transplantation

View Full Paper
Ask AI
Bookmark
Share

Authors

ADAlp Dinc-OranKMKhaoula MazouziNDNaval Daver

Discussion

Loading...

Member takes

Overview

Retrospective analysis reveals maintenance therapy shapes post-transplant relapse in FLT3-ITD acute myeloid leukemia.

Key Points

  • Median overall survival following relapse was 6.6 months among patients with FLT3-ITD acute myeloid leukemia.
  • Among 67 relapsed patients, 70% received maintenance therapy, with various combinations including venetoclax and hypomethylating agents.
  • Cytomolecular landscape analysis of pre- and post-transplant samples highlighted significant clonal dynamics influenced by maintenance treatment.
  • Findings underscore the need for improved post-transplant maintenance strategies targeting both FLT3-dependent and independent pathways.

Cite This Study

Dinc-Oran et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d95dhttps://doi.org/10.1182/blood-2025-592
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Detection of minute FLT3-ITD clones at day +30 post-allo-HSCT predicts high relapse risk and informs maintenance therapy in AML: A niche cohort study2025
  2. 2Impact of initial FLT3-ITD mutated clone numbers on clinical outcomes in Acute Myeloid Leukemia2025
  3. 3Diagnostic evaluation methods and prognostic impact of FLT3-ITD microclones in Acute Myeloid Leukemia (AML): A retrospective multicenter study on behalf of the EHA AML-specialized working group (SWG)2025 · 1 citations
  4. 4Prognostic factors for newly diagnosed Acute Myeloid Leukemia with FLT3-TKD - a multicenter retrospective study2025
  5. 5Clonal timing of FLT3-ITD dictates evolutionary trajectory and phenotypic heterogeneity in acute myeloid leukemia2025