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December 8, 2025BloodOpen Access

Bi-allelic TET2 alterations are frequently found in NPM1 mutated AML and constitute a distinct subgroup with unfavorable prognosis

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Authors

WWWencke WalterSKSarah KepplerTHTorsten Haferlach

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Overview

Analysis reveals that TET2dh mutations in NPM1 mutated AML reduce overall survival, indicating unique genetic roles.

Key Points

  • TET2dh mutations in NPM1 mutated AML reduce overall survival, highlighting unique prognosis implications.
  • 82% of TET2dh cases showed double mutations, with significant differences in overall survival observed.
  • Analysis involved clinical data and single-cell analysis of 479 patients with concurrent mutations.
  • The findings suggest the need for separate classification due to distinct genetic characteristics.

Cite This Study

Walter et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d929https://doi.org/10.1182/blood-2025-339
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic covariates associated with outcomes in patients with <i>NPM1</i>-mutated acute myeloid leukemia2025 · 3 citations
  2. 2DNMT3A, NPM1, and FLT3-ITD triple-mutated AML has a favorable prognosis in the era of FLT3 inhibitors2025 · 2 citations
  3. 3DNMT3A and NPM1 co-mutations in Acute Myeloid Leukemia (AML): A genomic landscape study2025
  4. 4Prognostic impact of co-occurring mutations in NPM1-mutated Acute Myeloid Leukemia2025
  5. 5Novel approaches to identify cellular vulnerabilities in TET2-dependent MDS2025