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December 8, 2025BloodOpen Access

Clinical translation of single cell measurable residual disease (scMRD) assay in real world Acute Myeloid Leukemia (AML) patients

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Authors

KMKatarina MicinFNFelipe NovoaAAAna C. Ayupe

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Overview

Prospective cohort analysis reveals scMRD's prognostic potential in AML, suggesting new avenues for MRD detection and treatment outcomes.

Key Points

  • The scMRD assay detected multiple AML mutant clones, with significant implications for monitoring residual disease status.
  • Patients receiving chemotherapy or HMA+Ven had their clinical outcomes assessed alongside scMRD results for consistency in MRD detection.
  • Bone marrow aspirates enriched for CD117+ cells were processed to evaluate the predictive capacity of scMRD in a real-world setting.
  • Integration of single-cell resolution into routine MRD practices may enhance early detection of clonal disease progression in AML patients.

Cite This Study

Micin et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6f1https://doi.org/10.1182/blood-2025-280
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1MRD-seq: A sensitive next generation sequencing-based approach for measurable residual disease detection in acute myeloid leukaemia2025
  2. 2Comparative evaluation of NGS-based MRD detection in AML using longitudinal matched bone marrow and blood samples2025
  3. 3Impact of minimal residual disease and next generation sequencing discordance in AML following induction with hypomethylating agent + venetoclax.2025
  4. 4A novel multi-target NGS application for molecular monitoring of measurable residual disease in Acute Myeloid Leukemia2025 · 2 citations
  5. 5Post-induction minimal residual disease assessment by flow cytometry and molecular biology enables prognostic stratification of patients with NPM1-mutated Acute Myeloid Leukemia: A dataml registry study.2025