What type of study is this?

This is a Human Clinical Trial study (also classified as: Systematic Review).

December 8, 2025BloodOpen Access

Wide variability and inconsistency in reporting of results of Myelodysplastic Syndromes/neoplasms (MDS) clinical trials: An icMDS systematic review of published manuscripts

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Authors

KPKelly PughThe Ohio State University TKTariq KewanMayo Clinic UPUwe PlatzbeckerNational Center for Tumor Diseases

Discussion

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Implication

Systematic review reveals inconsistent reporting of disease risk and response criteria in clinical trials for myelodysplastic syndromes, highlighting a need for standardization.

Key Points

Inconsistent reporting of clinical trial outcomes hampers interpretation and comparison between studies.
The systematic review identified 72 clinical trials, revealing variability in reporting response criteria for myelodysplastic syndromes.
Lower-risk and higher-risk disease cohorts showed different frequencies in endpoint definitions for safety and responses.
Standardized guidelines are crucial for improving clarity in myelodysplastic syndromes trial publications.

Cite This Study

Pugh et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d84c https://doi.org/10.1182/blood-2025-3852

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Implication

Systematic review reveals inconsistent reporting of disease risk and response criteria in clinical trials for myelodysplastic syndromes, highlighting a need for standardization.

Wide variability and inconsistency in reporting of results of Myelodysplastic Syndromes/neoplasms (MDS) clinical trials: An icMDS systematic review of published manuscripts

Discussion

Member takes

Implication

Key Points

Cite This Study

Wide variability and inconsistency in reporting of results of Myelodysplastic Syndromes/neoplasms (MDS) clinical trials: An icMDS systematic review of published manuscripts

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider