What type of study is this?

This is a Human Clinical Trial study.

December 8, 2025BloodOpen Access

Outcomes of clinical trial screening in patients with Myelodysplastic Syndromes and chronic myelomonocytic leukemia

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Authors

SHStephany HendricksonThe University of Texas MD Anderson Cancer Center ABAlexandre BazinetThe University of Texas MD Anderson Cancer Center DHDanielle HammondThe University of Texas MD Anderson Cancer Center

Discussion

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Implication

Analysis reveals that clinical trial enrollment improves survival for patients with chronic myelomonocytic leukemia, suggesting a need for broader eligibility criteria.

Key Points

Patients enrolled in clinical trials showed improved overall survival compared to those treated off protocol.
Screen failures were primarily due to patient/physician decisions and comorbid conditions, affecting survival outcomes.
The study evaluated clinical characteristics against survival outcomes using the Kaplan-Meier method and Cox proportional hazards model.
Trial enrollment is crucial for patients with hematologic malignancies like MDS and CMML, highlighting barriers to participation.

Cite This Study

Hendrickson et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d830 https://doi.org/10.1182/blood-2025-3867

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Implication

Analysis reveals that clinical trial enrollment improves survival for patients with chronic myelomonocytic leukemia, suggesting a need for broader eligibility criteria.

Outcomes of clinical trial screening in patients with Myelodysplastic Syndromes and chronic myelomonocytic leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

Outcomes of clinical trial screening in patients with Myelodysplastic Syndromes and chronic myelomonocytic leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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