What type of study is this?

This is a Human Clinical Trial study.

December 8, 2025BloodOpen Access

Burden and characteristics of infections in patients treated with bispecific antibodies and the impact of immunoglobulin replacement

View Full Paper

Ask AI

Bookmark

Authors

EKEfstathios KastritisNational and Kapodistrian University of Athens FTFoteini TheodorakakouNational and Kapodistrian University of Athens MMMagdalini MigkouKorea University

Discussion

Member takes

Implication

Observational analysis finds high infection risk in multiple myeloma patients treated with bispecific antibodies, suggesting immunoglobulin replacement may reduce infection burden.

Key Points

Infections occurred in 65.7% of patients, with a cumulative risk of 71% at 9 months, suggesting significant infection risk with bispecific antibody therapy.
Among 108 patients, viral infections accounted for 18% with respiratory tract infections being most common, highlighting the need for proactive prophylaxis.
Current analysis involved patients with relapsed/refractory multiple myeloma treated with bispecific antibodies, as infections were frequently microbial or opportunistic.
The implementation of immunoglobulin replacement was associated with reduced infection rates, emphasizing a critical role in patient management.

Cite This Study

Kastritis et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d7e2 https://doi.org/10.1182/blood-2025-2227

View Full Paper

Ask AI

Bookmark

Implication

Observational analysis finds high infection risk in multiple myeloma patients treated with bispecific antibodies, suggesting immunoglobulin replacement may reduce infection burden.

Burden and characteristics of infections in patients treated with bispecific antibodies and the impact of immunoglobulin replacement

Discussion

Member takes

Implication

Key Points

Cite This Study

Burden and characteristics of infections in patients treated with bispecific antibodies and the impact of immunoglobulin replacement

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider