What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

What question did this study set out to answer?

This research analyzes hematotoxicity and immune deficits associated with bispecific antibodies in lymphoma and multiple myeloma patients.

December 8, 2025BloodOpen Access

Hematotoxicity and immune deficits with bispecific antibodies: A systematic review and meta-analysis in lymphoma and multiple myeloma

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Authors

TTTobias TixLMU Klinikum ECEdward R. Scheffer CliffBrigham and Women's Hospital DHDoris K. HansenMoffitt Cancer Center

Discussion

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Implication

Meta-analysis reveals increased cytopenia rates in lymphoma and myeloma patients treated with bispecific antibodies, indicating a need for monitoring.

Key Points

This research analyzes hematotoxicity and immune deficits associated with bispecific antibodies in lymphoma and multiple myeloma patients.
Performed a systematic review and meta-analysis of studies on bispecific antibodies.
Included eligible adult patients with Non-Hodgkin Lymphoma or Multiple Myeloma.
Extracted cytopenia incidence and performed random effects models for pooled rates.
Pooled incidence of anemia was 38.7%, higher in multiple myeloma (49.2%) than lymphoma (30.7%).
Overall neutropenia incidence was 41.3%, with higher rates in multiple myeloma (51.8%).
Lymphopenia affected 24.9% of patients, significantly higher in multiple myeloma (32.9%).

Cite This Study

Tix et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1d0 https://doi.org/10.1182/blood-2025-8135

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Implication

Meta-analysis reveals increased cytopenia rates in lymphoma and myeloma patients treated with bispecific antibodies, indicating a need for monitoring.

Hematotoxicity and immune deficits with bispecific antibodies: A systematic review and meta-analysis in lymphoma and multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

Hematotoxicity and immune deficits with bispecific antibodies: A systematic review and meta-analysis in lymphoma and multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

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