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December 8, 2025Blood

Outcomes of stem cell transplantation in pediatric and adolescent/young adult patients with trisomy 21: A single-center experience

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Authors

OOOlayinka OkelejiPTPriti Tewari

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Overview

Retrospective analysis reveals HSCT improves outcomes in pediatric patients with Down syndrome having advanced acute leukemia, suggesting broader application may be beneficial.

Key Points

  • HSCT offers potential survival benefits for pediatric patients with Down syndrome who have relapsed leukemia and were in second complete remission.
  • Among three patients, two remain alive one year post-transplant, underlining the possibility of overcoming treatment-resistant disease.
  • Assessment involved retrospective chart review focusing on graft-vs-host disease, engraftment time, and transplant-related toxicities.
  • Managing viral reactivations and infections along with transplant toxicities are essential for improving outcomes.],

Cite This Study

Okeleji et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d734https://doi.org/10.1182/blood-2025-7742
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Allogeneic Hematopoietic Stem Cell Transplantation in Adolescents and Young Adults With Acute Lymphoblastic Leukemia-A Retrospective, Dual-Center Study.2025 · 1 citations
  2. 2Results of allogeneic hematopoietic stem cell transplantation from a genoidentical sibling after high-dose treosulfan-based conditioning in children with intermediate-risk acute myeloid leukemia in first clinical and hematological remission2025
  3. 3Allogeneic hematopoietic stem cell transplantation outcomes in pediatric acute lymphoblastic leukemia: A multicenter analysis from the cccg-ALL-2015 protocol2025
  4. 4Clinical efficacy of allogeneic hematopoietic stem cell transplantation in infant acute leukemia2025
  5. 5Combination of post-transplant cyclophosphamide and anti-thymocyte globulin for haploidentical stem cell transplantation in pediatric patients with acute leukemia2026