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October 8, 2025

Allogeneic Hematopoietic Stem Cell Transplantation in Adolescents and Young Adults With Acute Lymphoblastic Leukemia-A Retrospective, Dual-Center Study.

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Authors

OPOren PasvolskySSShai ShimonyRSRima M. Saliba

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Overview

Retrospective dual-center study highlights survival benefits in AYA patients with acute lymphoblastic leukemia, indicating effects of MRD and comorbidities.

Key Points

  • Overall survival at 3 years was 53%, with minimal residual disease status impacting outcomes significantly.
  • Among 164 patients, those with higher HCT-specific comorbidity index faced poorer overall survival and higher non-relapse mortality.
  • A majority of patients received myeloablative conditioning, highlighting treatment intensity in acute lymphoblastic leukemia management.
  • Chronic graft-versus-host disease occurred in 27% of patients, illustrating common post-transplant complications.

Cite This Study

Pasvolsky et al. (2025) studied this question.

synapsesocial.com/papers/68e6d7971ffa7aa7d63d1604https://doi.org/10.1002/ajh.70101
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world data of adolescents and young adults with acute lymphoblastic leukemia treated with a modified GMALL protocol in India: Treatment outcomes and challenges2025
  2. 2T-cell acute lymphoblastic leukemia: therapeutic outcomes in adolescents and young adults2025 · 2 citations
  3. 3Allogeneic hematopoietic stem cell transplantation outcomes in pediatric acute lymphoblastic leukemia: A multicenter analysis from the cccg-ALL-2015 protocol2025
  4. 4Outcomes after relapse for adolescent and young adult patients with ALL: Results from the Children's oncology group2025
  5. 5Outcomes of stem cell transplantation in pediatric and adolescent/young adult patients with trisomy 21: A single-center experience2025