The Indian experience with hydroxyurea in sickle cell disease: A 25-year systematic review

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Hydroxyurea significantly increased HbF levels by 10.9-77.3%, and reduced vaso-occlusive crises by 79-93%.
The treatment lowered transfusion requirements by 50-85%, indicating substantial improvement in patient care.
Analysis involved 27 studies with 3,817 patients, assessing key outcomes such as hospitalizations and adverse effects.
Hydroxyurea was generally safe with mild, reversible side effects like neutropenia, supporting its use in managing sickle cell disease.

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Systematic review highlights hydroxyurea's safety and effectiveness, improving HbF levels and reducing complications in sickle cell disease.

Jain et al. (2025) studied this question.

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Systematic review highlights hydroxyurea's safety and effectiveness, improving HbF levels and reducing complications in sickle cell disease.