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July 30, 2025BiomedicinesOpen Access

Revolutionizing Allogeneic Graft Tolerance Through Chimeric Antigen Receptor-T Regulatory Cells

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Authors

ACAlvin Man Lung ChanRSRajalingham SakthiswaryYLYogeswaran Lokanathan

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Overview

Systematic review demonstrates CAR-T regulatory cells improve graft survival in transplant models, suggesting new treatment avenues for graft rejection.

Key Points

  • CAR-T regulatory cells show greater graft protection than unmodified Tregs in transplant models.
  • HLA-A2-specific CAR-Tregs significantly improve graft survival and reduce inflammatory cytokines.
  • Including CD28 as a co-stimulatory domain enhances Treg function and stability.
  • Challenges like Treg exhaustion and reduced persistence remain, needing further optimization for clinical use.

Cite This Study

Chan et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cee43https://doi.org/10.3390/biomedicines13071757
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