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December 8, 2025BloodOpen Access

The role of ENO1 and chidamide in PTCL-NOS

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Authors

XGXuejiao GuZLZhenyu LiFZFeng Zhu

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Overview

Study reveals that ENO1 knockdown promotes apoptosis and inhibits cell proliferation in peripheral T cell lymphoma, indicating potential therapeutic pathways.

Key Points

  • Apoptosis was significantly enhanced following ENO1 knockdown, impacting peripheral T cell lymphoma cells.
  • Cell proliferation and migration were assessed using multiple assays, revealing critical mechanisms.
  • The method utilized involved flow cytometry and tumor microarray analysis to explore AMPK activation and reactive oxygen species levels.
  • Findings may enable targeted therapies against peripheral T cell lymphoma through manipulation of ENO1 and chidamide.

Cite This Study

Gu et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d69dhttps://doi.org/10.1182/blood-2025-7081
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Also Consider

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  1. 1ENO1 promotes Acute Myeloid Leukemia progression through SCD1-mediated lipid metabolism reprogramming2025 · 1 citations
  2. 2Alpha-enolase promotes progression of acute myeloid leukemia via MAPK/ERK signaling pathway.2025
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  4. 4<em>In Vitro</em> and <em>In Vivo</em> Characterization of ENOX2 (tNOX) Stemness Properties in Oral Cancer2025
  5. 5The NLP protein is a novel regulator of G2-m Phase of the cell cycle critical for proliferation of human peripheral T-cell lymphomas2025