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December 8, 2025BloodOpen Access

The NLP protein is a novel regulator of G2-m Phase of the cell cycle critical for proliferation of human peripheral T-cell lymphomas

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Authors

JOJana OpavskaAIAlexander M. IshovRORené Opavský

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Overview

Functional screening reveals NLP protein critical for apoptosis and malignancies in peripheral T-cell lymphomas.

Key Points

  • This research identifies the role of NLP protein in the G2-M phase of the cell cycle and its implications for therapy in peripheral T-cell lymphomas.
  • Functional screening to identify critical genes for PTCL cell survival.
  • Analysis of NLP gene expression in various lymphoma cases and solid tumors.
  • NLP knockout mice used to evaluate its role in vivo.
  • NLP is overexpressed in over 95% of PTCL cases and various solid tumors.
  • Loss of NLP induces G2-M arrest and mitotic catastrophe leading to apoptosis.
  • NLP depletion does not affect the proliferation of normal T-cells or fibroblasts.

Cite This Study

Opavska et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d15ehttps://doi.org/10.1182/blood-2025-5040
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