October 10, 2025Open Access

In Vitro and In Vivo Characterization of ENOX2 (tNOX) Stemness Properties in Oral Cancer

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In vitro and in vivo findings demonstrate that ENOX2 influences stemness properties in oral cancer cells, suggesting vital therapeutic implications.

Overexpression of enox2 significantly enhances stem cell properties and tumor formation in oral cancer cells.
Functional studies revealed that enox2 interacts with the stem cell factor sox2, influencing cancer cell behavior.
In vivo xenograft models showed that enox2-knockdown cells formed fewer tumors compared to enox2-overexpressing cells.
Protein expression of enox2 was notably higher in oral tumor tissues than in adjacent normal tissues, indicating its potential as a therapeutic target.

Wang et al. (2025) studied this question.

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October 10, 2025Open Access

View Full Paper

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Authors

In vitro and in vivo findings demonstrate that ENOX2 influences stemness properties in oral cancer cells, suggesting vital therapeutic implications.

Overexpression of enox2 significantly enhances stem cell properties and tumor formation in oral cancer cells.
Functional studies revealed that enox2 interacts with the stem cell factor sox2, influencing cancer cell behavior.
In vivo xenograft models showed that enox2-knockdown cells formed fewer tumors compared to enox2-overexpressing cells.
Protein expression of enox2 was notably higher in oral tumor tissues than in adjacent normal tissues, indicating its potential as a therapeutic target.

Wang et al. (2025) studied this question.

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