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December 8, 2025Blood

Impact of aspirin use on clinical outcomes in antiphospholipid syndrome patients with arterial thrombosis: A real-world cohort study

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Authors

MCMadhu Bhargavi ChandraZAZuhair Alam

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Overview

Retrospective cohort study finds higher bleeding complications with aspirin added to warfarin in APS patients.

Key Points

  • Aspirin use significantly increases risks for gastrointestinal bleeding and blood transfusion among APS patients.
  • Hazard ratios indicated elevated risks of ischemic stroke and acute myocardial infarction in the aspirin group.
  • Retrospective cohort analysis involved propensity score matching to balance demographics and comorbidities.
  • Findings highlight the need for caution in recommending aspirin with warfarin, as it raises bleeding risks without improving mortality.

Cite This Study

Chandra et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e34fhttps://doi.org/10.1182/blood-2025-952
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